A covalently linked phenanthridine-ruthenium(II) complex as a RNA probe.
نویسندگان
چکیده
A phenanthridine derivative covalently linked to a ruthenium complex yields an imaging probe whose fluorescence intensity and lifetime change substantially in the presence of RNA.
منابع مشابه
Two color RNA intercalating probe for cell imaging applications.
Here we report on a phenanthridine derivative which has a covalently linked fluorescein molecule in order to increase the light absorption and hence fluorescence signal intensity when bound to duplex RNA. Steady-state fluorescence shows that the energy transfer efficiency from the fluorescein to the phenanthridine fluorophore is approximately 77%, which results in the probe being over 5x bright...
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The highly regioselective ortho-arylation of acetanilides with aromatic boronic acids in the presence of a Ru(II) complex (3 mol%), AgSbF6 (12 mol%), Cu(OTf)2 (20 mol%) and Ag2O (1.0 eq.) is described. Later, ortho-arylated acetanilides were converted into phenanthridine and carbazole derivatives by using Ph3PO and Tf2O or palladium or Cu(OTf)2 catalysts.
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ورودعنوان ژورنال:
- Chemical communications
دوره 19 شماره
صفحات -
تاریخ انتشار 2009